The most common comment we hear during Rejuran HB consultations is, "I came because I heard it's less painful."
There's an expectation that it won't hurt because it contains lidocaine, but the reality we see in the clinic is a little different.
The product's ingredients are just the starting point. Actual perceived pain and satisfaction often depend on how the skin is assessed before the procedure and what pain-relief support processes are applied.
Today, for those considering Rejuran HB due to pain concerns, we will discuss two things we check before the product itself, from a clinical perspective.
Take just one minute to read this.
What kind of procedure is Rejuran HB?
Rejuran HB is a Skin Booster that adds hyaluronic acid and lidocaine to the existing Rejuran's PN (polynucleotide).
While it shares the method of directly injecting active ingredients into the skin, its purpose differs from procedures that fill volume or change facial contours.
The focus is always on improving the skin texture, inner dryness, and fine lines.
Therefore, the cases in which this procedure is typically recommended in the clinic are as follows:
- Skin that is dry and dull, causing makeup to not adhere well.
- Those who found the stinging sensation of traditional Rejuran uncomfortable and were looking for an alternative.
- Those concerned about fine lines or inner dryness but do not want intense procedures.
However, there is one point I would like to emphasize here.
Rejuran HB is not a procedure that ends with just injection.
Even within the same face, the forehead, eye area, cheeks, mouth area, and jaw each have different skin thickness and sensitivity, so dividing the areas can affect the completeness of the procedure.
Thin and highly mobile areas like the eye and mouth areas require more delicate attention, while wider areas like the cheeks require consideration of both injection intervals and balance.
Is pain determined by the product?
This is why it's difficult to give a definitive answer to the question, "Does Rejuran HB not hurt because it contains lidocaine?"
While lidocaine can assist in pain relief during the procedure, the actual perceived pain can vary depending on individual skin thickness, sensitivity, the level of tension on the day, and the treated area.
Especially in areas where the skin is thin or close to bone, such as around the eyes, mouth, and forehead, some individuals may react more sensitively to pain.
When comparing traditional Rejuran and Rejuran HB from an ingredient perspective, it can be summarized as follows:
| Category | Traditional Rejuran | Rejuran HB |
|---|---|---|
| Key Ingredients | PN (Polynucleotide) | PN plus Hyaluronic Acid, Lidocaine |
| Ingredient Focus | Skin condition management | Condition management with added hydration and pain relief support |
| Approach to Pain | Primarily separate supportive care | Ingredient support combined with procedural care |
As shown in the table, Rejuran HB is indeed designed to reduce pain discomfort in terms of ingredients.
However, it is important to also consider that pain is not entirely resolved by the product alone, and that supportive care applied during the procedure can influence the actual perceived sensation.
How to interpret the pain of Rejuran-type treatments has been discussed in a similar vein in the article Revisiting Rejuran, which is said to be better the more painful it is, from a clinical perspective.
First, we assess the face by dividing it into areas.
To perform Rejuran HB meticulously, we first examine the overall skin condition of the face.
Identifying which areas are particularly dry or where fine lines are prominent in advance can help reduce situations where certain areas are excessively concentrated or where the actual problem areas are less addressed.
At O.N Clinic, before the procedure, we use 'Muse,' a skin analyzer with AI capabilities, to assess the skin condition and areas of concern. Then, considering the overall balance of the face, we design the treatment scope and injection method.
Since it is a procedure involving multiple small injections, it is important to approach it by checking the condition of each area rather than rushing to finish quickly.
Adjusting the injection depth and interval according to individual skin thickness and sensitivity is also determined at this stage.
The process of checking skin condition before the procedure is not just a simple step, but a starting point for creating a personalized treatment plan. The more specific you are about your concerns during the pre-consultation, the more accurate the plan will be.
If you are curious about how we divide the approach by area, you may also find it helpful to refer to the article Skin Booster Selection Criteria, which explains when we first recommend Skin Boosters for fine lines around the eyes and forehead.
If you have many questions about pain before starting, you can organize them in advance by consulting via chat now.
Second, were pain-reducing processes applied?
The second point of verification is to consider not only the product's characteristics but also the supportive care applied during the procedure to reduce pain discomfort.
The actual sequence applied in the clinic is roughly as follows:
- Before the procedure, cryo-anesthesia is used to reduce skin irritation. The cold temperature can temporarily desensitize the treated area, which may help reduce the stinging or burning sensation felt during injection.
- During the procedure, a vibrator may be used as needed. Vibratory stimulation can help distract from injection pain, potentially alleviating discomfort during the procedure.
Given the nature of the procedure, which involves injecting into multiple areas of the face, these two processes work to reduce both psychological tension and perceived pain.
Since Rejuran-type treatments involve direct injection into the skin, it is difficult to say that there is no pain at all.
Therefore, rather than relying solely on the expectation that the product will be less painful, it is more realistic to also consider how processes like cooling and vibration are applied.
In the same context, you can continue to read about how oil-water imbalance in summer and Rejuran are designed in sequence in the article Oil-Water Imbalance and Rejuran Design Sequence.
Why is post-procedure soothing care important?
After Rejuran HB treatment, some individuals may experience embossing (small bumps at the injection site), redness, warmth, swelling, or bruising.
(※ These are common reactions that can occur after injection procedures and usually subside over time, but the degree of discomfort and duration can vary depending on individual skin condition.)
At O.N Clinic, we provide post-procedure soothing care to calm irritated skin and reduce warmth, helping the skin stabilize more comfortably.
Since immediate post-procedure care can affect the recovery experience, it is important not to skip soothing care.
In rare cases, inflammation, infection, or allergic reactions may occur. If abnormal symptoms persist or worsen, it is safer to visit the clinic promptly for an examination rather than making self-judgments.
In summary, Rejuran HB is more likely to lead to a satisfactory experience when not only the product's characteristics but also pre-procedure skin assessment, customized approach by area, pain-relief supportive care, and post-procedure soothing care are all integrated.
If you are concerned about skin texture or inner dryness and are worried about pain, we recommend checking your current skin condition and then scheduling a consultation in a way that suits you.
If you are also concerned about sunken cheeks and Lifting & Tightening, you may find it helpful to refer to the article Criteria for Checking Sunken Cheeks in Sinnonhyeon Alltite Lifting to help guide your direction.
Consult via chat
Frequently Asked Questions
What is the difference between Rejuran HB and traditional Rejuran?
Rejuran HB is a product that adds hyaluronic acid and lidocaine to the PN ingredient of traditional Rejuran.
Hyaluronic acid can assist in skin hydration, and lidocaine can assist in pain relief during the procedure, so those who found the pain of traditional Rejuran uncomfortable may consider it.
How painful is the Rejuran HB procedure?
Since it is injected directly into the skin, it is difficult to say that there is no pain at all.
The degree of pain can vary depending on individual skin thickness, sensitivity, tension level, and the treated area.
Supportive care such as cryo-anesthesia and the use of a vibrator can help reduce discomfort.
What reactions can occur after the procedure?
Some individuals may experience embossing, redness, warmth, swelling, or bruising.
Most of these reactions tend to subside over time, but the degree and duration can vary from person to person.
If abnormal symptoms persist or worsen, it is necessary to have them checked by a medical professional.
Why is it important to check skin condition before the procedure?
Because even within the same face, the skin thickness and sensitivity vary from area to area.
Identifying which areas are dry or where fine lines are prominent in advance helps to appropriately adjust the injection depth and interval, and to create a plan that sufficiently addresses the areas of concern.
What skin concerns can be considered for this procedure?
It can be considered by individuals concerned about dull skin texture, inner dryness, fine lines, and overall rough skin condition.
Since it is a procedure focused on overall skin condition management rather than volume enhancement or changes in facial contours, it is advisable to confirm through a pre-consultation whether it aligns with your goals.
Recovery and Downtime: How long until I feel comfortable?
Rejuran HB is a Skin Booster injected directly into the skin, so immediately after the procedure, you may notice embossing (small bumps) at the injection site, redness, swelling, numbness, and, rarely, bruising.
(※ Embossing tends to subside as the injected ingredients are absorbed, and redness or numbness often fades within a few days, but the duration and intensity can vary from person to person.)
On the day of the procedure, avoiding activities that add heat and irritation, such as hot saunas, strenuous exercise, and alcohol consumption, and focusing on soothing and moisturizing care can make the recovery experience more comfortable.
If swelling or redness lasts longer than expected, or if pain worsens, it is safer to visit the clinic to have your condition checked rather than making self-judgments.
How is the cost structured?
The cost of Rejuran HB is not simply determined by the number of ccs.
The composition can vary depending on the treatment area (whether it's the entire face or specific areas like the eyes or forehead), the product volume and number of sessions used, pain-relief support processes like cryo-anesthesia and vibration, and whether post-procedure soothing care is included.
The composition may also change if multiple areas are injected meticulously, or if it is designed in conjunction with other Skin Boosters or procedures.
Therefore, for an accurate cost, it is best to confirm your skin condition and desired scope during a consultation.
We recommend checking what is included in the price rather than deciding based solely on promotional lowest prices.
Visit and Consultation Information
O.N Clinic is located in Gangnam, Seoul, making it easily accessible on foot from Gangnam Station Exit 11.
For Rejuran HB, pre-procedure skin condition assessment and area-specific planning are important, so if you organize your concerns about specific areas and pain beforehand, the consultation will be smoother.
For reservations and inquiries, please consult via chat now, and we will guide you according to your visit time.
Author: Dr. Oh Seung-Min (Chief Director of O.N Clinic, graduated from Seoul National University College of Medicine, Academic Committee Chairman of the Korean Laser Dermatology and Hair Society). For more details on his background, please refer to Medical Staff Introduction.
First published 2026-06-09 / Last reviewed 2026-08-15
This article is for general informational purposes only, and appropriate treatment and results may vary depending on individual conditions.
