blog-224455470749

Key summary: Rejuran and Hylowave are both called skin boosters, but they play different roles. Rejuran supports a recovery environment for tired skin overall, while Hylowave fills in moisture and the skin barrier and, when needed, can also be considered for volume. So the starting point is not which product is better, but first separating whether your concern is skin texture or lost volume.

When you search for skin boosters, Rejuran and Hylowave appear side by side, so in the clinic we are often asked which of the two works better. We do not answer this question with a product name; instead we ask back whether skin texture or lost volume bothers you more.

This article covers in order what Rejuran and Hylowave each do, how to think about Rejuran dose and pain, and the division of the face into zones that we decide before choosing a product.

The main ingredient of Rejuran Healer is PN (polynucleotide) obtained from salmon, and it is a skin booster that places this ingredient directly into the dermis. Because it works toward creating an environment where the skin's own recovery can take place, it tends to come up first when the skin of the whole face looks tired rather than one particular area.

For example, skin that has thinned, texture that has roughened or an increase in fine lines are typical situations where Rejuran is considered first. You can understand it as a skin booster weighted toward lifting the base condition of the skin rather than filling a specific area.

Hylowave is characterized by combining small-molecule and large-molecule hyaluronic acid in one formulation. Many clinics now use it for hollow side cheeks or temples, so many people know it as a volume product, but quite a few people also look for it as a skin booster.

Hylowave is a minimally cross-linked formulation and is known to help hold moisture in the skin and settle the barrier so moisture stays longer. It is also explained that skin density and elasticity gradually follow over time. So people with deep dryness, makeup that often flakes or sensitive skin tend to consider it as a skin booster, and since it can sometimes be done with fewer injections depending on the injection method, people who want to reduce the burden of treatment are interested as well.

Of course, people whose side cheeks and temples have hollowed and cast shadows also choose Hylowave for a subtle sense of volume. Being usable in both directions, improving skin texture and replenishing volume, is a character unique to Hylowave.

Both skin boosters share the point that the treatment does not end the moment they are injected; change tends to rise slowly over time. The two products are also similar in that small bumps, an embossed look, may briefly show where injected.

In the end, Rejuran is weighted toward overall skin recovery, and Hylowave toward filling moisture and the barrier and, when needed, volume as well. It is more accurate to see them as doing different jobs than to see one as superior.

What people deliberate over longest before Rejuran is usually how many cc they should get, and whether it is okay since it is said to hurt a lot. Starting with dose, many people assume a larger amount means a larger effect.

However, even the same amount feels different depending on whether it is concentrated where the concerns gather or spread thinly over the whole face. So at O.N Clinic we do not fix the Rejuran dose first; we check the skin condition and extent and then decide the amount.

Pain is related to the sticky nature of the PN ingredient. As thick PN is pushed into the dermis it creates a heavy, aching sensation, and with needles repeatedly touching many spots on the face, quite a few people find it hard.

What we suggest as an alternative for such people is Rejuran HB. Rejuran HB is a line that mixes PN with hyaluronic acid and the local anesthetic lidocaine, so many people who want less pain and more hydration choose it. Still, the degree of pain varies with area, skin thickness and each person's sensitivity, so no line, including Rejuran HB, can be said to be painless.

If you miss whether the issue is skin texture or volume, even a good skin booster ends up used in the wrong place. That is why, when planning a skin booster at O.N Clinic, we divide the face into three areas.

The first is the focus zone: areas where texture is rough and thin, or areas that have hollowed and cast shadows. Where skin texture is the concern we think with Rejuran at the center, and where lost volume is the concern, with Hylowave at the center.

The second is the protection zone. The eye area and temples, where vessels run under thin skin, can react strongly even to small amounts, so we approach them carefully with a shallow injection depth and a reduced amount.

The third is the leave-alone zone: areas where skin texture and volume are judged to be fine already. Filling such areas unnecessarily can make the face look puffy instead, so not touching them is also part of the design. That is why we do not proceed right away just on a request for 2cc of Rejuran.

When needed we split Rejuran and Hylowave within one face, and when one is enough we recommend just one. Getting both together does not double the result. Before planning, we confirm thickness, moisture level and skin texture in numbers with tools such as an AI skin analyzer, and after the skin booster we follow the course of the change as it settles.

In one line, Rejuran takes care of the base condition of the skin, and Hylowave takes care of hydration and volume. If you look at it in the order of first separating where to focus, where to protect and where to leave alone, the skin booster that suits your skin becomes much clearer.

I am afraid of injections. Is there a way to make it hurt less?

You can consider a line that contains a local anesthetic, or reduce the burden by adjusting the amount and depth in sensitive areas. How painful it feels varies a lot between individuals, so if you tend to be fearful, it is best to mention it at the consultation first.

If my texture is rough and my cheeks are hollow too, do I need both Rejuran and Hylowave?

For a face with both concerns, one option is to divide by zone, such as Rejuran for rough areas and Hylowave for hollow areas. It is better to first identify which concern stands out more and then decide the order and how far to go.

I am worried about the bumps that rose after treatment

Embossing is a temporary bulge that forms while the injected solution stays in the skin, and it mostly flattens out as time passes. If swelling and pain grow worse over time instead, do not wait; let the clinic that treated you know right away.

O.N Clinic is near Gangnam Station, so it is fairly easy to reach by subway.

If you are deciding between Rejuran and Hylowave, noting whether skin texture or lost volume bothers you most, along with your previous skin booster experience, will make the consultation easier. If you have any questions, feel free to chat with us now.

Author: Dr. Oh Seung-min (Chief Director of O.N Clinic, graduate of Seoul National University College of Medicine, Chair of the Scientific Committee of the Korean Society for Laser, Skin and Hair). See the full profile on the medical team page. First published 2026-10-27, last reviewed 2026-11-10

This article is for general information only, and the appropriate treatment and outcome may differ depending on each person's condition.