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Key summary: 2cc of Rejuran Healer is a commonly chosen amount for the whole face, but even the same 2cc feels different in effect and pain depending on what depth and method are used. Manual injection allows fine changes in depth and amount for each area, while Dermashine is strong at filling wide surfaces evenly in a short time. So rather than insisting on one of the two, designing by area is better for managing both the results and the pain of 2cc of Rejuran Healer.

When about to book 2cc of Rejuran Healer, many people hesitate between quick machine injection and manual injection placed point by point. Coming across Rejuran reviews saying it hurts quite a bit makes the deliberation even longer.

At O.N Clinic we do not insist on a single injection method. This means we do not see Dermashine as always better, or manual injection as the only answer. This article first covers the results and pain of 2cc of Rejuran Healer, then compares manual injection and Dermashine, and finally lays out how we actually divide the face by area.

The main ingredient of Rejuran Healer is salmon-derived PN (polynucleotide), and it is a skin booster that places this into the dermis. Unlike a filler, which creates volume by filling, it works toward supporting an environment where the skin recovers on its own.

This is why Rejuran Healer comes to mind first when roughened texture, fine lines or a dry-from-within feeling is the concern. It is easy to understand as laying a sturdy base under thinned skin. Rather than right after injection, smoothness and firmness gradually build as several weeks pass.

2cc is an amount commonly chosen for the whole face. However, even the same 2cc of Rejuran Healer feels different in effect depending on the method and the depth at which it goes in.

Pain cannot be avoided as a topic. The PN in Rejuran Healer is fairly viscous, so an aching pressure can be felt as it goes in, and the repeated needle entries are a burden too. After injection, small embossed bumps may remain visible at each needle point for a day or two.

These bumps are a phenomenon that arises while PN spreads and settles within the dermis, so they usually flatten on their own. And how pain and embossing appear depends on whether manual injection or Dermashine is used.

Manual injection is a method in which the doctor places Rejuran Healer point by point directly with a needle. Its biggest advantage is that depth and amount can be changed by area, allowing fine control such as shallow, small amounts in thin areas like under the eyes, and slightly deeper placement in sunken scars or hollow areas.

In return, the number of needle entries increases, so the treatment takes longer and the bumps at injection points can be relatively noticeable. Because each needle entry is felt one by one, some people feel the pain lasts longer. To ease this burden, O.N Clinic also uses methods such as a vibration device, numbing cream and cooling gas.

Dermashine is an injection device in which, when a tip with several fine needles is placed on the skin, the machine automatically pushes in the solution. It is designed to cover several points at once while delivering a set amount at a preset depth.

So it is good for even placement over wide surfaces such as the cheeks, and the treatment time is relatively short; many people feel that as the time shortens, so does the time they must endure pain. On the other hand, since the depth is always the same, fine control may be lacking in areas with strong contours or very thin skin.

We often hear claims that machine injection hurts less or that manual injection works better, but in reality the two methods simply have different areas they do well. Dermashine is strong at covering wide surfaces evenly, and manual injection at narrow, delicate areas. So instead of asking which hurts less, it helps far more to change the question to which areas of your face receive it and by which method.

In a Rejuran Healer consultation at O.N Clinic, manual injection versus Dermashine is decided last. Before that, we measure thickness, texture and the location of sunken spots by area with the AI skin analyzer MUSE, and also check facial structures such as bone and vessels.

For under the eyes and the forehead, where bone contours lie right beneath the skin, and for areas where vessels pass, we use manual injection to match the depth point by point. The wide, flat cheeks are left to Dermashine for even placement. For people with especially thin skin, even on the same cheeks we set a shallower depth and a smaller amount to reduce strain.

That is why we tend to avoid finishing everything, even under the eyes, in one go with Dermashine alone, though if someone very sensitive to pain wants Dermashine, we respect that choice. Conversely, densely filling the entire cheeks with manual injection alone often gains little compared with the embossing and time involved.

How the set amount of 2cc of Rejuran Healer is distributed across the face, and by which method, is the design that changes both the felt results and the pain. After injection we watch the bumps subside and the skin smooth out before scheduling the next Rejuran Healer session. O.N Clinic's principle is to look first at what the patient's skin needs rather than at a trending injection method.

Manual injection or Dermashine is a question that can be answered only after reading your face first. A plan that divides the work, Dermashine for even coverage of the wide cheeks and manual injection for careful work in thin, contoured areas, is the core of satisfaction with 2cc of Rejuran Healer.

The bumps are still there the next day

While PN spreads in the skin, bumps may remain for about a day or two, and they generally disappear if you wait. On the other hand, if swelling and pain increase day by day, it is safer to let the clinic that treated you know right away and have it checked.

The area under my eyes is thin and looks hollow. Can I get Rejuran Healer there?

Under the eyes, bone lies right beneath thin skin, so it is an area where depth and amount must be set most carefully. After measuring the degree of hollowness and the thickness, we decide together whether to proceed and whether to use manual injection.

I am sensitive to pain. Is it okay for me to get injections?

Even with the same Rejuran Healer, how much it hurts depends on the method, the area and how long the treatment takes. If you tell us your sensitive areas in advance, we can adjust the split between manual injection and Dermashine and the order of treatment to reduce the burden.

O.N Clinic is near Gangnam Station, so it is fairly easy to reach by subway.

If you are deciding between manual injection and Dermashine for 2cc of Rejuran Healer, noting the areas that concern you most and your sensitivity to pain will make the consultation on dividing injection methods easier. If you have any questions, feel free to chat with us now.

Author: Dr. Oh Seung-min (Chief Director of O.N Clinic, graduate of Seoul National University College of Medicine, Chair of the Scientific Committee of the Korean Society for Laser, Skin and Hair). See the full profile on the medical team page. First published 2026-10-14, last reviewed 2026-11-10

This article is for general information only, and the appropriate treatment and outcome may differ depending on each person's condition.